JGNAHS

EDITORIAL

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J Gandhara Nurs Alli Health Sci

January - June 2025

A PERSPECTIVE ON PLATELET-DERIVED PRODUCTS FOR REGENERATIVE MEDICINE

Muhammad Rizwan Alam

In modern health sciences, cell-based therapies have emerged as one of the most transformative approaches for

treating a variety of diseases. In this regard, autologous platelets and their products have garnered signicant

attention in regenerative medicine. With a pivotal contribution in hemostasis, platelets are rich in cytokines,

growth factors and numerous bioactive molecules with tremendous potential in tissue repair and regeneration.

The generation of extracellular vesicles including microvesicles and exosomes from activated platelets have also

been demonstrated to participate in intercellular transport of dierent types of biomolecules including protein,

nucleic acids and small molecules, that has strong therapeutic potential.

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limited to, sports medicine, dermatology, cosmetology, ophthalmology and orthopedics. Its low cost and ease of

preparation from a relatively small volume of blood makes it a promising therapeutic strategy for treating several

acute and chronic injuries. The concentrated platelets in PRP release growth factors such as platelet-derived

growth factor (PDGF), vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF-β),

and epidermal growth factor (EGF), all of which contribute to several cellular processes including tissue repair,

angiogenesis, collagen synthesis, and inammation modulation. PRP has shown potential in the treatment of

musculoskeletal injuries, bone fractures, wound repair, and hair regeneration by promoting healing and reducing

recovery time, though outcomes can vary depending on preparation protocols, injury type, and patient factors.

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Beyond

PRP and PRF, platelet-derived growth factors (PDGFs) and extracellular vesicles (EVs) are emerging as novel

therapeutic modalities. PDGFs, which are present in high concentrations in platelets, regulate cellular processes

such as migration, proliferation, and angiogenesis. These growth factors are essential for wound healing and

tissue regeneration. EVs, including exosomes, are released by platelets that carry bioactive molecules, including

proteins, lipids, and RNA, which impacts cellular behavior. EVs have been shown to promote tissue repair,

enhance angiogenesis, and modulate immune responses, making them an attractive tool for regenerative

applications. The application of platelet-derived EVs is in the research phase, but their potential to deliver

targeted therapeutic eects makes them a promising approach for future regenerative therapies.

still developing. Although, the PRP is an autologous biological product that often falls outside the scope of

traditional pharmaceutical regulation, there is still a need to develop specific guidelines and regulations by

ensuring standardized protocols and devices for safe and eective patient care.